As part of their 50th anniversary, New Scientist published 50-year forecasts from over 70 scientists.
A couple highlights (mostly cut-and-pasted shamelessly from the above link):

Francis Collins: Genetic advances will allow entire generations of us to live happily into our hundreds
Edward O. Wilson: The biggest leap in biogeography and conservation biology will be the near-complete mapping of [...]

Recognizing natural human evolution is likely over, Popular Mecanics is carrying a story on technological trends and advancements that will build better humans.
Update – New Scientist is running a similar article.

The Savvy Technologist recorded a podcast interview with Ray Kurzweil and notes:
One of his main points was that most people don’t appreciate the exponential nature of technological advancement. Most change appears linear in the near term, but the linear model breaks down once the timeframe gets out beyond a few years.

Link to the blog post.